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Tetracycline Effects on Candida Albicans Virulence Factors
Joint Authors
McCool, Logan
Essmann, Michael
Mai, Hanh
Larsen, Bryan
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Object.
To determine if tetracycline, previously reported to increase the probability of developing symptomatic vaginal yeast infections, has a direct effect on Candida albicans growth or induction of virulent phenotypes.
Method.
In vitro, clinical isolates of yeast were cultivated with sublethal concentrations of tetracycline and yeast cell counts, hyphal formation, drug efflux pump activity, biofilm production, and hemolysin production were determined by previously reported methods.
Results.
Tetracycline concentrations above 150 μg/mL inhibited Candida albicans, but at submicrogram/mL, a modest growth increase during the early hours of the growth curve was observed.
Tetracycline did not inhibit hyphal formation at sublethal concentrations.
Hypha formation appeared augmented by exposure to tetracycline in the presence of chemically defined medium and especially in the presence of human serum.
Efflux pump CDR1 was upregulated and a nonsignificant trend toward increased biofilm formation was noted.
Conclusion.
Tetracycline appears to have a small growth enhancing effect and may influence virulence through augmentation of hypha formation, and a modest effect on drug efflux and biofilm formation, although tetracycline did not affect hemolysin.
It is not clear if the magnitude of the effect is sufficient to attribute vaginitis following tetracycline treatment to direct action of tetracycline on yeast.
American Psychological Association (APA)
McCool, Logan& Mai, Hanh& Essmann, Michael& Larsen, Bryan. 2008. Tetracycline Effects on Candida Albicans Virulence Factors. Infectious Diseases in Obstetrics and Gynecology،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-476058
Modern Language Association (MLA)
McCool, Logan…[et al.]. Tetracycline Effects on Candida Albicans Virulence Factors. Infectious Diseases in Obstetrics and Gynecology No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-476058
American Medical Association (AMA)
McCool, Logan& Mai, Hanh& Essmann, Michael& Larsen, Bryan. Tetracycline Effects on Candida Albicans Virulence Factors. Infectious Diseases in Obstetrics and Gynecology. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-476058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476058