Tau and Caspase 3 as Targets for Neuroprotection

المؤلفون المشاركون

Gozes, Illana
Idan-Feldman, Anat
Ostritsky, Regina

المصدر

International Journal of Alzheimer's Disease

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-05-30

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

The peptide drug candidate NAP (davunetide) has demonstrated protective effects in various in vivo and in vitro models of neurodegeneration.

NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death.

Recent studies suggest that caspases may play a role in tau pathology.

The purpose of this study was to evaluate the effect of NAP on tau hyperphosphorylation and caspase activity in the same biological system.

Our experimental setup used primary neuronal cultures subjected to oxygen-glucose deprivation (OGD), with and without NAP or caspase inhibitor.

Cell viability was assessed by measuring mitochondrial activity (MTS assay), and immunoblots were used for analyzing protein level.

It was shown that apoptosis was responsible for all cell death occurring following ischemia, and NAP treatment showed a concentration-dependent protection from cell death.

Ischemia caused an increase in the levels of active caspase-3 and hyperphosphorylated tau, both of which were prevented by either NAP or caspase-inhibitor treatment.

Our data suggest that, in this model system, caspase activation may be an upstream event to tau hyperphosphorylation, although additional studies will be required to fully elucidate the cascade of events.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Idan-Feldman, Anat& Ostritsky, Regina& Gozes, Illana. 2012. Tau and Caspase 3 as Targets for Neuroprotection. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476074

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Idan-Feldman, Anat…[et al.]. Tau and Caspase 3 as Targets for Neuroprotection. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-476074

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Idan-Feldman, Anat& Ostritsky, Regina& Gozes, Illana. Tau and Caspase 3 as Targets for Neuroprotection. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476074

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-476074