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Tau and Caspase 3 as Targets for Neuroprotection
Joint Authors
Gozes, Illana
Idan-Feldman, Anat
Ostritsky, Regina
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The peptide drug candidate NAP (davunetide) has demonstrated protective effects in various in vivo and in vitro models of neurodegeneration.
NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death.
Recent studies suggest that caspases may play a role in tau pathology.
The purpose of this study was to evaluate the effect of NAP on tau hyperphosphorylation and caspase activity in the same biological system.
Our experimental setup used primary neuronal cultures subjected to oxygen-glucose deprivation (OGD), with and without NAP or caspase inhibitor.
Cell viability was assessed by measuring mitochondrial activity (MTS assay), and immunoblots were used for analyzing protein level.
It was shown that apoptosis was responsible for all cell death occurring following ischemia, and NAP treatment showed a concentration-dependent protection from cell death.
Ischemia caused an increase in the levels of active caspase-3 and hyperphosphorylated tau, both of which were prevented by either NAP or caspase-inhibitor treatment.
Our data suggest that, in this model system, caspase activation may be an upstream event to tau hyperphosphorylation, although additional studies will be required to fully elucidate the cascade of events.
American Psychological Association (APA)
Idan-Feldman, Anat& Ostritsky, Regina& Gozes, Illana. 2012. Tau and Caspase 3 as Targets for Neuroprotection. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476074
Modern Language Association (MLA)
Idan-Feldman, Anat…[et al.]. Tau and Caspase 3 as Targets for Neuroprotection. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-476074
American Medical Association (AMA)
Idan-Feldman, Anat& Ostritsky, Regina& Gozes, Illana. Tau and Caspase 3 as Targets for Neuroprotection. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476074