DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response

المؤلفون المشاركون

Schlesinger, Michael
Levy, Paloma
Rabinowitz, Ruth
Jakobovich, Einat
Granot, Esther

المصدر

Mediators of Inflammation

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-09-18

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day.

Aim.

To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response.

Methods.

60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum.

From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production.

Results.

CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group.

Proportion of CD4 and CD8 cells producing IFNγ significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells.

Immunoglobulins and anti-HBs levels did not differ between groups.

Conclusions.

In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFNγ production is compatible with attenuation of a proinflammatory response.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Granot, Esther& Jakobovich, Einat& Rabinowitz, Ruth& Levy, Paloma& Schlesinger, Michael. 2011. DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476110

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Granot, Esther…[et al.]. DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response. Mediators of Inflammation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-476110

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Granot, Esther& Jakobovich, Einat& Rabinowitz, Ruth& Levy, Paloma& Schlesinger, Michael. DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476110

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-476110