DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response
Joint Authors
Schlesinger, Michael
Levy, Paloma
Rabinowitz, Ruth
Jakobovich, Einat
Granot, Esther
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day.
Aim.
To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response.
Methods.
60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum.
From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production.
Results.
CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group.
Proportion of CD4 and CD8 cells producing IFNγ significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells.
Immunoglobulins and anti-HBs levels did not differ between groups.
Conclusions.
In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFNγ production is compatible with attenuation of a proinflammatory response.
American Psychological Association (APA)
Granot, Esther& Jakobovich, Einat& Rabinowitz, Ruth& Levy, Paloma& Schlesinger, Michael. 2011. DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476110
Modern Language Association (MLA)
Granot, Esther…[et al.]. DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response. Mediators of Inflammation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-476110
American Medical Association (AMA)
Granot, Esther& Jakobovich, Einat& Rabinowitz, Ruth& Levy, Paloma& Schlesinger, Michael. DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476110