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Comparison of Helicobacter bilis-Associated Protein Expression in Huh7 Cells Harbouring HCV Replicon and in Replicon-Cured Cells
المؤلفون المشاركون
Raftery, Mark J.
Mendz, George L.
Okoli, Arinze S.
المصدر
International Journal of Hepatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-30
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide.
Hepatitis B or C infections are the main causes of HCC with hepatitis C being the major risk factor for liver cancer in the developed countries.
Recently, complications with bacteria of the genus Helicobacter have been associated with HCV-induced HCC.
To further understand the mechanisms leading to the development of HCC in the presence of HCV and/or Helicobacter spp., investigation of the differential protein expression in Huh7 cells harbouring HCV-replicon, and replicon cured-Huh7 cells cocultured with H.
bilis was done employing two-dimensional gel electrophoresis and mass spectrometry.
In the transfected-Huh7 cells exposed to sublethal inoculum densities of H.
bilis, 53 different proteins were identified comprising of 28 upregulated and 16 downregulated proteins including 9 potential protein isoforms; in the cured Huh7 cells, 45 different proteins were identified including 33 upregulated, 8 downregulated and, 9 potential protein isoforms.
H.
bilis affected the modulation of proteins involved in different pathways of Huh7-derived cells physiology including proteins involved in the progression from dysplasia to neoplasm.
The result also indicated that the response of the Huh7-derived cells to the presence of H.
bilis depended on whether or not HCV replicon was present.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okoli, Arinze S.& Raftery, Mark J.& Mendz, George L.. 2012. Comparison of Helicobacter bilis-Associated Protein Expression in Huh7 Cells Harbouring HCV Replicon and in Replicon-Cured Cells. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-476601
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okoli, Arinze S.…[et al.]. Comparison of Helicobacter bilis-Associated Protein Expression in Huh7 Cells Harbouring HCV Replicon and in Replicon-Cured Cells. International Journal of Hepatology No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-476601
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okoli, Arinze S.& Raftery, Mark J.& Mendz, George L.. Comparison of Helicobacter bilis-Associated Protein Expression in Huh7 Cells Harbouring HCV Replicon and in Replicon-Cured Cells. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-476601
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476601
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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