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Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?
المؤلفون المشاركون
Agarwal, Sanjay
Chiong, Valerie J.
Baruch, Lawrence
Gupta, Bhanu
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To determine if non-HDL cholesterol (N-HDL) and directly measured LDL cholesterol (D-LDL) are clinically equivalent measurements.
Patients and Methods.
Eighty-one subjects recruited for 2 cholesterol treatment studies had at least 1 complete fasting lipid panel and D-LDL performed simultaneously; 64 had a second assessment after 4 to 6 weeks, resulting in 145 triads of C-LDL, D-LDL, and N-HDL.
To directly compare N-HDL to D-LDL and C-LDL, we normalized the N-HDL by subtracting 30 from the N-HDL (N-HDLA).
Results.
There was significant correlation between N-HDLA, D-LDL, and C-LDL.
Correlation was significantly greater between N-HDLA and C-LDL than between N-HDLA and D-LDL.
A greater than 20 mg/dL difference between measures was observed more commonly between N-HDLA and D-LDL, 29%, than between C-LDL and N-HDLA, 11% (P<0.001), and C-LDL and D-LDL, 17% (P=0.028).
Clinical discordance was most common, and concordance was least common between N-HDL and D-LDL.
Conclusions.
Our findings suggest that N-HDL cholesterol and D-LDL cholesterol are not clinically equivalent and frequently discordant.
As N-HDL may be superior to even C-LDL for predicting events in statin-treated patients, utilizing N-HDL to guide therapy would appear to be preferable to D-LDL when C-LDL is inaccurate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baruch, Lawrence& Chiong, Valerie J.& Agarwal, Sanjay& Gupta, Bhanu. 2013. Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?. Cholesterol،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476742
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baruch, Lawrence…[et al.]. Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?. Cholesterol No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-476742
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baruch, Lawrence& Chiong, Valerie J.& Agarwal, Sanjay& Gupta, Bhanu. Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?. Cholesterol. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476742
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476742
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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