Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?
Joint Authors
Agarwal, Sanjay
Chiong, Valerie J.
Baruch, Lawrence
Gupta, Bhanu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To determine if non-HDL cholesterol (N-HDL) and directly measured LDL cholesterol (D-LDL) are clinically equivalent measurements.
Patients and Methods.
Eighty-one subjects recruited for 2 cholesterol treatment studies had at least 1 complete fasting lipid panel and D-LDL performed simultaneously; 64 had a second assessment after 4 to 6 weeks, resulting in 145 triads of C-LDL, D-LDL, and N-HDL.
To directly compare N-HDL to D-LDL and C-LDL, we normalized the N-HDL by subtracting 30 from the N-HDL (N-HDLA).
Results.
There was significant correlation between N-HDLA, D-LDL, and C-LDL.
Correlation was significantly greater between N-HDLA and C-LDL than between N-HDLA and D-LDL.
A greater than 20 mg/dL difference between measures was observed more commonly between N-HDLA and D-LDL, 29%, than between C-LDL and N-HDLA, 11% (P<0.001), and C-LDL and D-LDL, 17% (P=0.028).
Clinical discordance was most common, and concordance was least common between N-HDL and D-LDL.
Conclusions.
Our findings suggest that N-HDL cholesterol and D-LDL cholesterol are not clinically equivalent and frequently discordant.
As N-HDL may be superior to even C-LDL for predicting events in statin-treated patients, utilizing N-HDL to guide therapy would appear to be preferable to D-LDL when C-LDL is inaccurate.
American Psychological Association (APA)
Baruch, Lawrence& Chiong, Valerie J.& Agarwal, Sanjay& Gupta, Bhanu. 2013. Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?. Cholesterol،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476742
Modern Language Association (MLA)
Baruch, Lawrence…[et al.]. Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?. Cholesterol No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-476742
American Medical Association (AMA)
Baruch, Lawrence& Chiong, Valerie J.& Agarwal, Sanjay& Gupta, Bhanu. Discordance of Non-HDL and Directly Measured LDL Cholesterol : Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?. Cholesterol. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476742