Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis
المؤلفون المشاركون
Hijioka, Masayuki
Jensen, Robert T.
Oono, Takamasa
Nakamura, Taichi
Suzuki, Koichi
Uchida, Masahiko
Ito, Tetsuhide
Igarashi, Hisato
Niina, Yusuke
Fujimori, Nao
Takayanagi, Ryoichi
المصدر
International Journal of Inflammation
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Pancreatitis is an inflammatory disease of unknown causes.
There are many triggers causing pancreatitis, such as alcohol, common bile duct stone, virus and congenital or acquired stenosis of main pancreatic duct, which often involve tissue injuries.
Pancreatitis often occurs in sterile condition, where the dead/dying pancreatic parenchymal cells and the necrotic tissues derived from self-digested-pancreas were observed.
However, the causal relationship between tissue injury and pancreatitis and how tissue injury could induce the inflammation of the pancreas were not elucidated fully until now.
This study demonstrates that cytosolic double-stranded DNA increases the expression of several inflammatory genes (cytokines, chemokines, type I interferon, and major histocompatibility complex) in rat pancreatic stellate cells.
Furthermore, these increase accompanied the multiple signal molecules genes, such as interferon regulatory factors, nuclear factor-kappa B, low-molecular-weight protein 2, and transporter associated with antigen processing 1.
We suggest that this phenomenon is a plausible mechanism that might explain how cell damage of the pancreas or tissue injury triggers acute, chronic, and autoimmune pancreatitis; it is potentially relevant to host immune responses induced during alcohol consumption or other causes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakamura, Taichi& Ito, Tetsuhide& Igarashi, Hisato& Uchida, Masahiko& Hijioka, Masayuki& Oono, Takamasa…[et al.]. 2012. Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-476851
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakamura, Taichi…[et al.]. Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis. International Journal of Inflammation No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-476851
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakamura, Taichi& Ito, Tetsuhide& Igarashi, Hisato& Uchida, Masahiko& Hijioka, Masayuki& Oono, Takamasa…[et al.]. Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-476851
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476851
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر