Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis
Joint Authors
Hijioka, Masayuki
Jensen, Robert T.
Oono, Takamasa
Nakamura, Taichi
Suzuki, Koichi
Uchida, Masahiko
Ito, Tetsuhide
Igarashi, Hisato
Niina, Yusuke
Fujimori, Nao
Takayanagi, Ryoichi
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pancreatitis is an inflammatory disease of unknown causes.
There are many triggers causing pancreatitis, such as alcohol, common bile duct stone, virus and congenital or acquired stenosis of main pancreatic duct, which often involve tissue injuries.
Pancreatitis often occurs in sterile condition, where the dead/dying pancreatic parenchymal cells and the necrotic tissues derived from self-digested-pancreas were observed.
However, the causal relationship between tissue injury and pancreatitis and how tissue injury could induce the inflammation of the pancreas were not elucidated fully until now.
This study demonstrates that cytosolic double-stranded DNA increases the expression of several inflammatory genes (cytokines, chemokines, type I interferon, and major histocompatibility complex) in rat pancreatic stellate cells.
Furthermore, these increase accompanied the multiple signal molecules genes, such as interferon regulatory factors, nuclear factor-kappa B, low-molecular-weight protein 2, and transporter associated with antigen processing 1.
We suggest that this phenomenon is a plausible mechanism that might explain how cell damage of the pancreas or tissue injury triggers acute, chronic, and autoimmune pancreatitis; it is potentially relevant to host immune responses induced during alcohol consumption or other causes.
American Psychological Association (APA)
Nakamura, Taichi& Ito, Tetsuhide& Igarashi, Hisato& Uchida, Masahiko& Hijioka, Masayuki& Oono, Takamasa…[et al.]. 2012. Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-476851
Modern Language Association (MLA)
Nakamura, Taichi…[et al.]. Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis. International Journal of Inflammation No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-476851
American Medical Association (AMA)
Nakamura, Taichi& Ito, Tetsuhide& Igarashi, Hisato& Uchida, Masahiko& Hijioka, Masayuki& Oono, Takamasa…[et al.]. Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells : A Plausible Mechanism for Tissue Injury-Associated Pancreatitis. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-476851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476851