Optimization on Preparation Condition of Propolis Flavonoids Liposome by Response Surface Methodology and Research of Its Immunoenhancement Activity
المؤلفون المشاركون
Liu, Xu
Lu, Yu
Yuan, Ju
Liu, Jiaguo
Fan, Yunpeng
Zhao, Xiaojuan
Wang, Deyun
Abula, Saifuding
Hu, Yuanliang
Liu, Cui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of this study is to prepare propolis flavonoids liposome (PFL) and optimize the preparation condition and to investigate further whether liposome could promote the immunoenhancement activity of propolis flavonoids (PF).
PFL was prepared with ethanol injection method, and the preparation conditions of PFL were optimized with response surface methodology (RSM).
Moreover, the immunoenhancement activity of PFL and PF in vitro was determined.
The result showed that the optimal preparation conditions for PFL by response surface methodology were as follows: ratio of lipid to drug (w/w) 9.6 : 1, ratio of soybean phospholipid to cholesterol (w/w) 8.5 : 1, and speed of injection 0.8 mL·min−1.
Under these conditions, the experimental encapsulation efficiency of PFL was 91.67 ± 0.21%, which was close to the predicted value.
Therefore, the optimized preparation condition is very reliable.
Moreover, the results indicated that PFL could not only significantly promote lymphocytes proliferation singly or synergistically with PHA, but also increase expression level of IL-2 and IFN-γ mRNA.
These indicated that liposome could significantly improve the immunoenhancement activity of PF.
PFL demonstrates the significant immunoenhancement activity, which provides the theoretical basis for the further experiment in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Ju& Lu, Yu& Abula, Saifuding& Hu, Yuanliang& Liu, Jiaguo& Fan, Yunpeng…[et al.]. 2013. Optimization on Preparation Condition of Propolis Flavonoids Liposome by Response Surface Methodology and Research of Its Immunoenhancement Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-476987
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Ju…[et al.]. Optimization on Preparation Condition of Propolis Flavonoids Liposome by Response Surface Methodology and Research of Its Immunoenhancement Activity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-476987
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Ju& Lu, Yu& Abula, Saifuding& Hu, Yuanliang& Liu, Jiaguo& Fan, Yunpeng…[et al.]. Optimization on Preparation Condition of Propolis Flavonoids Liposome by Response Surface Methodology and Research of Its Immunoenhancement Activity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-476987
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-476987
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر