Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats
المؤلفون المشاركون
Shivamogga Rajanna, Santosh Kumar
Krishnappa, Pradeepa
Venkatesh,
Kashi Prakash Gupta, Rajesh
Venkatarangaiah, Krishna
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-02
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Delonix elata L.
(Ceasalpinaceae), is widely used by the traditional medical practitioners of Karnataka, India, to cure jaundice, and bronchial and rheumatic problems.
The objective of this study was to screen the in vitro antioxidant and hepatoprotective activity of the stem bark extracts against CCl4-induced liver damage in rats.
Among different stem bark extracts tested, the ethanol extract (DSE) has shown significant in vitro antioxidant property in radicals scavenging, metal chelating, and lipid peroxidation inhibition assays.
HPLC analysis of the DSE revealed the presence of known antioxidant molecules, namely, gallic acid, ellagic acid, coumaric acid, quercetin, and rutin.
Bioassay-guided fractionation of DSE has resulted in the isolation and characterization of quercetin.
DSE and quercetin have shown significant prophylactic effects by restoring the liver function markers (AST, ALT, ALP, serum bilirubin, and total protein) and antioxidant enzymes (SOD, CAT, GPx, and GST).
These results were proved to be hepatoprotective at par with silymarin and well supported by the histological observations of liver sections with distinct hepatic cells, and mild degree of fatty change and necrosis.
The results indicated that the DSE and quercetin were significant for prophylactic activity against CCl4-induced liver damage in rats.
This activity could be attributed to the antioxidant constituents in the DSE and hence justified the ethnomedicinal claims.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Krishnappa, Pradeepa& Venkatarangaiah, Krishna& Venkatesh, & Shivamogga Rajanna, Santosh Kumar& Kashi Prakash Gupta, Rajesh. 2014. Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-477179
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Krishnappa, Pradeepa…[et al.]. Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-477179
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Krishnappa, Pradeepa& Venkatarangaiah, Krishna& Venkatesh, & Shivamogga Rajanna, Santosh Kumar& Kashi Prakash Gupta, Rajesh. Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-477179
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477179
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر