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Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats
Joint Authors
Shivamogga Rajanna, Santosh Kumar
Krishnappa, Pradeepa
Venkatesh,
Kashi Prakash Gupta, Rajesh
Venkatarangaiah, Krishna
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Delonix elata L.
(Ceasalpinaceae), is widely used by the traditional medical practitioners of Karnataka, India, to cure jaundice, and bronchial and rheumatic problems.
The objective of this study was to screen the in vitro antioxidant and hepatoprotective activity of the stem bark extracts against CCl4-induced liver damage in rats.
Among different stem bark extracts tested, the ethanol extract (DSE) has shown significant in vitro antioxidant property in radicals scavenging, metal chelating, and lipid peroxidation inhibition assays.
HPLC analysis of the DSE revealed the presence of known antioxidant molecules, namely, gallic acid, ellagic acid, coumaric acid, quercetin, and rutin.
Bioassay-guided fractionation of DSE has resulted in the isolation and characterization of quercetin.
DSE and quercetin have shown significant prophylactic effects by restoring the liver function markers (AST, ALT, ALP, serum bilirubin, and total protein) and antioxidant enzymes (SOD, CAT, GPx, and GST).
These results were proved to be hepatoprotective at par with silymarin and well supported by the histological observations of liver sections with distinct hepatic cells, and mild degree of fatty change and necrosis.
The results indicated that the DSE and quercetin were significant for prophylactic activity against CCl4-induced liver damage in rats.
This activity could be attributed to the antioxidant constituents in the DSE and hence justified the ethnomedicinal claims.
American Psychological Association (APA)
Krishnappa, Pradeepa& Venkatarangaiah, Krishna& Venkatesh, & Shivamogga Rajanna, Santosh Kumar& Kashi Prakash Gupta, Rajesh. 2014. Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-477179
Modern Language Association (MLA)
Krishnappa, Pradeepa…[et al.]. Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-477179
American Medical Association (AMA)
Krishnappa, Pradeepa& Venkatarangaiah, Krishna& Venkatesh, & Shivamogga Rajanna, Santosh Kumar& Kashi Prakash Gupta, Rajesh. Antioxidant and Prophylactic Effects of Delonix elata L., Stem Bark Extracts, and Flavonoid Isolated Quercetin against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-477179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477179