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Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors
المؤلفون المشاركون
do Nascimento, José Luiz Martins
Da Cunha, Maura
Monteiro, Vanessa Sâmia da Conçeição
Sawada, Luis Armando
Dias, Germana Bueno
Rabelo, Guilherme Rodrigues
Bastos, Gilmara de Nazareth Tavares
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Libidibia ferrea (LF) is a medicinal plant that holds many pharmacological properties.
We evaluated the antinociceptive effect in the LF aqueous seed extract and Lipidic Portion of Libidibia ferrea (LPLF), partially elucidating their mechanisms.
Histochemical tests and Gas chromatography of the LPLF were performed to characterize its fatty acids.
Acetic acid-induced abdominal constriction, formalin-induced pain, and hot-plate test in mice were employed in the study.
In all experiments, aqueous extract or LPLF was administered systemically at the doses of 1, 5, and 10 mg/kg.
LF aqueous seed extract and LPLF demonstrated a dose-dependent antinociceptive effect in all tests indicating both peripheral anti-inflammatory and central analgesia properties.
Also, the use of atropine (5 mg/kg), naloxone (5 mg/kg) in the abdominal writhing test was able to reverse the antinociceptive effect of the LPLF, indicating that at least one of LF lipids components is responsible for the dose related antinociceptive action in chemical and thermal models of nociception in mice.
Together, the present results suggested that Libidibia ferrea induced antinociceptive activity is possibly related to its ability to inhibit opioid, cholinergic receptors, and cyclooxygenase-2 pathway, since its main component, linoleic acid, has been demonstrated to produce such effect in previous studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sawada, Luis Armando& Monteiro, Vanessa Sâmia da Conçeição& Rabelo, Guilherme Rodrigues& Dias, Germana Bueno& Da Cunha, Maura& do Nascimento, José Luiz Martins…[et al.]. 2014. Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-477246
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sawada, Luis Armando…[et al.]. Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-477246
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sawada, Luis Armando& Monteiro, Vanessa Sâmia da Conçeição& Rabelo, Guilherme Rodrigues& Dias, Germana Bueno& Da Cunha, Maura& do Nascimento, José Luiz Martins…[et al.]. Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-477246
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477246
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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