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Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors
Joint Authors
do Nascimento, José Luiz Martins
Da Cunha, Maura
Monteiro, Vanessa Sâmia da Conçeição
Sawada, Luis Armando
Dias, Germana Bueno
Rabelo, Guilherme Rodrigues
Bastos, Gilmara de Nazareth Tavares
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Libidibia ferrea (LF) is a medicinal plant that holds many pharmacological properties.
We evaluated the antinociceptive effect in the LF aqueous seed extract and Lipidic Portion of Libidibia ferrea (LPLF), partially elucidating their mechanisms.
Histochemical tests and Gas chromatography of the LPLF were performed to characterize its fatty acids.
Acetic acid-induced abdominal constriction, formalin-induced pain, and hot-plate test in mice were employed in the study.
In all experiments, aqueous extract or LPLF was administered systemically at the doses of 1, 5, and 10 mg/kg.
LF aqueous seed extract and LPLF demonstrated a dose-dependent antinociceptive effect in all tests indicating both peripheral anti-inflammatory and central analgesia properties.
Also, the use of atropine (5 mg/kg), naloxone (5 mg/kg) in the abdominal writhing test was able to reverse the antinociceptive effect of the LPLF, indicating that at least one of LF lipids components is responsible for the dose related antinociceptive action in chemical and thermal models of nociception in mice.
Together, the present results suggested that Libidibia ferrea induced antinociceptive activity is possibly related to its ability to inhibit opioid, cholinergic receptors, and cyclooxygenase-2 pathway, since its main component, linoleic acid, has been demonstrated to produce such effect in previous studies.
American Psychological Association (APA)
Sawada, Luis Armando& Monteiro, Vanessa Sâmia da Conçeição& Rabelo, Guilherme Rodrigues& Dias, Germana Bueno& Da Cunha, Maura& do Nascimento, José Luiz Martins…[et al.]. 2014. Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-477246
Modern Language Association (MLA)
Sawada, Luis Armando…[et al.]. Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-477246
American Medical Association (AMA)
Sawada, Luis Armando& Monteiro, Vanessa Sâmia da Conçeição& Rabelo, Guilherme Rodrigues& Dias, Germana Bueno& Da Cunha, Maura& do Nascimento, José Luiz Martins…[et al.]. Libidibia ferrea Mature Seeds Promote Antinociceptive Effect by Peripheral and Central Pathway : Possible Involvement of Opioid and Cholinergic Receptors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-477246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477246