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High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism
المؤلفون المشاركون
Collino, Massimo
Fantozzi, Roberto
Rogazzo, Mara
Minetto, Marco Alessandro
Benetti, Elisa
Mastrocola, Raffaella
Chiazza, Fausto
Aragno, Manuela
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Peroxisome Proliferator Activated Receptor (PPAR)-δ agonists may serve for treating metabolic diseases.
However, the effects of PPAR-δ agonism within the skeletal muscle, which plays a key role in whole-body glucose metabolism, remain unclear.
This study aimed to investigate the signaling pathways activated in the gastrocnemius muscle by chronic administration of the selective PPAR-δ agonist, GW0742 (1 mg/kg/day for 16 weeks), in male C57Bl6/J mice treated for 30 weeks with high-fructose corn syrup (HFCS), the major sweetener in foods and soft-drinks (15% wt/vol in drinking water).
Mice fed with the HFCS diet exhibited hyperlipidemia, hyperinsulinemia, hyperleptinemia, and hypoadiponectinemia.
In the gastrocnemius muscle, HFCS impaired insulin and AMP-activated protein kinase signaling pathways and reduced GLUT-4 and GLUT-5 expression and membrane translocation.
GW0742 administration induced PPAR-δ upregulation and improvement in glucose and lipid metabolism.
Diet-induced activation of nuclear factor-κB and expression of inducible-nitric-oxide-synthase and intercellular-adhesion-molecule-1 were attenuated by drug treatment.
These effects were accompanied by reduction in the serum concentration of interleukin-6 and increase in muscular expression of fibroblast growth factor-21.
Overall, here we show that PPAR-δ activation protects the skeletal muscle against the metabolic abnormalities caused by chronic HFCS exposure by affecting multiple levels of the insulin and inflammatory cascades.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Benetti, Elisa& Mastrocola, Raffaella& Rogazzo, Mara& Chiazza, Fausto& Aragno, Manuela& Fantozzi, Roberto…[et al.]. 2013. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Benetti, Elisa…[et al.]. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-477325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Benetti, Elisa& Mastrocola, Raffaella& Rogazzo, Mara& Chiazza, Fausto& Aragno, Manuela& Fantozzi, Roberto…[et al.]. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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