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Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis
المؤلفون المشاركون
Norton, Gavin R.
Woodiwiss, Angela J.
Dessein, Patrick H.
Gonzalez-Gay, Miguel A.
Solomon, Ahmed
Tsang, Linda
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA.
Circulating soluble E-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 concentrations were measured in 217 African patients (112 black and 105 white) with RA.
In comprehensive confounder adjusted mixed regression models, 5 conventional and 4 nonconventional cardiovascular risk factors were associated (P=0.05 to <0.0001) with endothelial activation.
Interleukin-6 was the only risk factor related to each endothelial activation molecule and independently contributed by 18% and significantly more than other risk factors to the variation in overall endothelial activation as estimated by an SD (z) score of endothelial activation molecule concentrations.
The independent interleukin-6-overall endothelial activation relationships were reproduced in various subgroups.
Interleukin-6 concentrations relate consistently, markedly, and to a larger extent than other cardiovascular risk factors to endothelial activation in RA.
Assessment of interleukin-6 concentrations may enhance cardiovascular risk stratification in RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dessein, Patrick H.& Solomon, Ahmed& Woodiwiss, Angela J.& Norton, Gavin R.& Tsang, Linda& Gonzalez-Gay, Miguel A.. 2013. Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477383
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dessein, Patrick H.…[et al.]. Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-477383
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dessein, Patrick H.& Solomon, Ahmed& Woodiwiss, Angela J.& Norton, Gavin R.& Tsang, Linda& Gonzalez-Gay, Miguel A.. Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477383
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477383
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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