Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis
Joint Authors
Norton, Gavin R.
Woodiwiss, Angela J.
Dessein, Patrick H.
Gonzalez-Gay, Miguel A.
Solomon, Ahmed
Tsang, Linda
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We examined the potential impact of conventional compared with nonconventional cardiovascular risk factors including interleukin-6 levels on endothelial activation in RA.
Circulating soluble E-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 concentrations were measured in 217 African patients (112 black and 105 white) with RA.
In comprehensive confounder adjusted mixed regression models, 5 conventional and 4 nonconventional cardiovascular risk factors were associated (P=0.05 to <0.0001) with endothelial activation.
Interleukin-6 was the only risk factor related to each endothelial activation molecule and independently contributed by 18% and significantly more than other risk factors to the variation in overall endothelial activation as estimated by an SD (z) score of endothelial activation molecule concentrations.
The independent interleukin-6-overall endothelial activation relationships were reproduced in various subgroups.
Interleukin-6 concentrations relate consistently, markedly, and to a larger extent than other cardiovascular risk factors to endothelial activation in RA.
Assessment of interleukin-6 concentrations may enhance cardiovascular risk stratification in RA.
American Psychological Association (APA)
Dessein, Patrick H.& Solomon, Ahmed& Woodiwiss, Angela J.& Norton, Gavin R.& Tsang, Linda& Gonzalez-Gay, Miguel A.. 2013. Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477383
Modern Language Association (MLA)
Dessein, Patrick H.…[et al.]. Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-477383
American Medical Association (AMA)
Dessein, Patrick H.& Solomon, Ahmed& Woodiwiss, Angela J.& Norton, Gavin R.& Tsang, Linda& Gonzalez-Gay, Miguel A.. Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477383