Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals
المؤلفون المشاركون
Massara, Cristiano Lara
Carvalho, Omar dos Santos
Corrêa-Oliveira, Rodrigo
Bethony, Jeffrey Michael
Freitas, Paula Albuquerque
Geiger, Stefan Michael
Fujiwara, Ricardo Toshio
المصدر
Journal of Parasitology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We compared the effects of larval and adult worm excretory-secretory (ES) products from hookworm on the proliferative responses and cytokine secretion in peripheral blood mononuclear cells (PBMCs) from hookwormpatients and egg-negative, nonendemic controls.
When compared with negative controls, mitogen-stimulated PBMC from hookworm-infected individuals showed a significantly reduced proliferative response when adult worm ES antigen was added to the cultures.
Furthermore, in hookworm-infected individuals a significant downmodulation of inflammatory interleukin (IL)-6 and tumor necrosis factor (TNF)-α secretion resulted when PBMCs were stimulated with mitogen in combination with larval or adult worm ES.
Both, interferon (IFN)-γ and IL-10 secretion were significantly lower in stimulated PBMC from infected individuals; however the IFN-γ/IL-10 ratio was much lower in hookworm-infected patients.
Comparable effects, although at lower concentrations, were achieved when PBMCs from both groups were incubated with living hookworm third-stage larvae.
We suggest that hookworm ES products downmodulate proliferative responses and inflammation during the chronic phase of the disease and facilitate early larval survival or adult worm persistence in the gut.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Geiger, Stefan Michael& Fujiwara, Ricardo Toshio& Freitas, Paula Albuquerque& Massara, Cristiano Lara& Carvalho, Omar dos Santos& Corrêa-Oliveira, Rodrigo…[et al.]. 2011. Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477476
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Geiger, Stefan Michael…[et al.]. Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals. Journal of Parasitology Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-477476
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Geiger, Stefan Michael& Fujiwara, Ricardo Toshio& Freitas, Paula Albuquerque& Massara, Cristiano Lara& Carvalho, Omar dos Santos& Corrêa-Oliveira, Rodrigo…[et al.]. Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477476
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477476
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر