Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals
Joint Authors
Massara, Cristiano Lara
Carvalho, Omar dos Santos
Corrêa-Oliveira, Rodrigo
Bethony, Jeffrey Michael
Freitas, Paula Albuquerque
Geiger, Stefan Michael
Fujiwara, Ricardo Toshio
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We compared the effects of larval and adult worm excretory-secretory (ES) products from hookworm on the proliferative responses and cytokine secretion in peripheral blood mononuclear cells (PBMCs) from hookwormpatients and egg-negative, nonendemic controls.
When compared with negative controls, mitogen-stimulated PBMC from hookworm-infected individuals showed a significantly reduced proliferative response when adult worm ES antigen was added to the cultures.
Furthermore, in hookworm-infected individuals a significant downmodulation of inflammatory interleukin (IL)-6 and tumor necrosis factor (TNF)-α secretion resulted when PBMCs were stimulated with mitogen in combination with larval or adult worm ES.
Both, interferon (IFN)-γ and IL-10 secretion were significantly lower in stimulated PBMC from infected individuals; however the IFN-γ/IL-10 ratio was much lower in hookworm-infected patients.
Comparable effects, although at lower concentrations, were achieved when PBMCs from both groups were incubated with living hookworm third-stage larvae.
We suggest that hookworm ES products downmodulate proliferative responses and inflammation during the chronic phase of the disease and facilitate early larval survival or adult worm persistence in the gut.
American Psychological Association (APA)
Geiger, Stefan Michael& Fujiwara, Ricardo Toshio& Freitas, Paula Albuquerque& Massara, Cristiano Lara& Carvalho, Omar dos Santos& Corrêa-Oliveira, Rodrigo…[et al.]. 2011. Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477476
Modern Language Association (MLA)
Geiger, Stefan Michael…[et al.]. Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals. Journal of Parasitology Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-477476
American Medical Association (AMA)
Geiger, Stefan Michael& Fujiwara, Ricardo Toshio& Freitas, Paula Albuquerque& Massara, Cristiano Lara& Carvalho, Omar dos Santos& Corrêa-Oliveira, Rodrigo…[et al.]. Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477476