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Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents
المؤلف
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-08-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The [Pd(DEEN)Cl2] and [Pt(DEEN)Cl2] complexes were synthesized and characterized where DEEN=N,N-diethylethylenediamine.
The stoichiometry and stability of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and [Pd(DEEN)(H2O)2]2+ were investigated at 37∘C and 0.16 M ionic strength.
The stability constant of the complexes formed in solution were determined and the binding centres of the ligands were assigned.
The concentration distribution diagrams of the complexes were evaluated The equilibrium constants for the displacement of representative coordinated ligands such as inosine, glycine or methionine by cysteine were calculated and the concentration distribution diagrams of the various species were evaluated.
The kinetics of base hydrolysis of free and coordinated S-methylcysteine methyl ester was investigated.
The mechanism of hydrolysis was discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shoukry, Eman Mohamed. 2009. Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-477557
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shoukry, Eman Mohamed. Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-477557
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shoukry, Eman Mohamed. Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-477557
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477557
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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