Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents
Author
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The [Pd(DEEN)Cl2] and [Pt(DEEN)Cl2] complexes were synthesized and characterized where DEEN=N,N-diethylethylenediamine.
The stoichiometry and stability of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and [Pd(DEEN)(H2O)2]2+ were investigated at 37∘C and 0.16 M ionic strength.
The stability constant of the complexes formed in solution were determined and the binding centres of the ligands were assigned.
The concentration distribution diagrams of the complexes were evaluated The equilibrium constants for the displacement of representative coordinated ligands such as inosine, glycine or methionine by cysteine were calculated and the concentration distribution diagrams of the various species were evaluated.
The kinetics of base hydrolysis of free and coordinated S-methylcysteine methyl ester was investigated.
The mechanism of hydrolysis was discussed.
American Psychological Association (APA)
Shoukry, Eman Mohamed. 2009. Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-477557
Modern Language Association (MLA)
Shoukry, Eman Mohamed. Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-477557
American Medical Association (AMA)
Shoukry, Eman Mohamed. Equilibrium and Kinetic Investigations of the Interaction of Model Platinum(II) Complex with DNA Constituents in Reference to the Antitumour Activity : Complex-Formation Reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-477557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477557
