In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients
المؤلفون المشاركون
Isogai, Hideto
Ueta, Mayumi
Kinoshita, Shigeru
Hirayama, Noriaki
Sotozono, Chie
Tokunaga, Katsushi
Miyadera, Hiroko
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الطب البشري
الملخص EN
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug hypersensitivities with high mortality.
Typical over-the-counter drugs of cold medicines are suggested to be causative.
As multiple ingredients are generally contained in cold medicines, it is of particular interest to investigate which ingredients are responsible for SJS/TEN.
However, experimental examination of causal relationships between SJS/TEN and a particular drug molecule is not straightforward.
Significant association between HLA-A*02:06 and SJS/TEN with severe ocular surface complications has been observed in the Japanese.
In the present study, we have undertaken in silico docking simulations between various ingredients contained in cold medicines available in Japan and the HLA-A*02:06 molecule.
We use the composite risk index (CRI) that is the absolute value of the binding affinity multiplied by the daily dose to assess the potential risk of the adverse reactions.
The drugs which have been recognized as causative drugs of SJS/TEN in Japan have revealed relatively high CRI, and the association between SJS/TEN and HLA-A*02:06 has been qualitatively verified.
The results have also shown that some drugs whose links to SJS/TEN have not been clinically recognized in Japan show the high CRI and suggested that attention should be paid to their adverse drug reactions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Isogai, Hideto& Miyadera, Hiroko& Ueta, Mayumi& Sotozono, Chie& Kinoshita, Shigeru& Tokunaga, Katsushi…[et al.]. 2013. In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477671
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Isogai, Hideto…[et al.]. In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. Journal of Toxicology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-477671
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Isogai, Hideto& Miyadera, Hiroko& Ueta, Mayumi& Sotozono, Chie& Kinoshita, Shigeru& Tokunaga, Katsushi…[et al.]. In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477671
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477671
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر