In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients
Joint Authors
Isogai, Hideto
Ueta, Mayumi
Kinoshita, Shigeru
Hirayama, Noriaki
Sotozono, Chie
Tokunaga, Katsushi
Miyadera, Hiroko
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug hypersensitivities with high mortality.
Typical over-the-counter drugs of cold medicines are suggested to be causative.
As multiple ingredients are generally contained in cold medicines, it is of particular interest to investigate which ingredients are responsible for SJS/TEN.
However, experimental examination of causal relationships between SJS/TEN and a particular drug molecule is not straightforward.
Significant association between HLA-A*02:06 and SJS/TEN with severe ocular surface complications has been observed in the Japanese.
In the present study, we have undertaken in silico docking simulations between various ingredients contained in cold medicines available in Japan and the HLA-A*02:06 molecule.
We use the composite risk index (CRI) that is the absolute value of the binding affinity multiplied by the daily dose to assess the potential risk of the adverse reactions.
The drugs which have been recognized as causative drugs of SJS/TEN in Japan have revealed relatively high CRI, and the association between SJS/TEN and HLA-A*02:06 has been qualitatively verified.
The results have also shown that some drugs whose links to SJS/TEN have not been clinically recognized in Japan show the high CRI and suggested that attention should be paid to their adverse drug reactions.
American Psychological Association (APA)
Isogai, Hideto& Miyadera, Hiroko& Ueta, Mayumi& Sotozono, Chie& Kinoshita, Shigeru& Tokunaga, Katsushi…[et al.]. 2013. In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477671
Modern Language Association (MLA)
Isogai, Hideto…[et al.]. In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. Journal of Toxicology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-477671
American Medical Association (AMA)
Isogai, Hideto& Miyadera, Hiroko& Ueta, Mayumi& Sotozono, Chie& Kinoshita, Shigeru& Tokunaga, Katsushi…[et al.]. In Silico Risk Assessment of HLA-A*02 : 06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477671