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Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese
المؤلفون المشاركون
Zhou, Zhongjun
Zhu, Tingzhun
Zhang, Fengju
Wu, Yudong
Li, Yang
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-06-02
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Pathological myopia is a severe hereditary ocular disease leading to blindness.
It is urgent and very important to find the pathogenesis and therapy for this disease.
The purpose of the study is to analyze sequences of lumican and decorin genes with pathological myopia(PM) and control subjects to verify the relationship between lumican, decorin genes and PM in Northern Han Chinese.
We collected and analyzed the blood samples of 94 adults (including 12 pedigree cases and 82 sporadic cases) with PM and 90 controls in the northern Han ethnic Chinese.
Genotyping was performed by direct sequencing after polymerase chain reaction(PCR) amplification and allele frequencies were tested for Hardy-Weinberg equilibrium.
Univariate analysis revealed significant differences between two groups for three SNPs: rs3759223 (C→T) and rs17853500 (T→C) of the lumican gene and rs74419 (T→C) of decorin gene with (P<.05) for all their genotype distribution and allele frequency.
There is no significant difference for incidence of these mutations between pedigree and sporadic group (P>.05).
The results suggested that the sequence variants in 5′-regulatory region of lumican gene and 3'UTR of decorin gene were associated significantly with PM in Northern Han Chinese.
Further studies are needed to confirm finally whether the two genes are the virulence genes of PM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Fengju& Zhu, Tingzhun& Zhou, Zhongjun& Wu, Yudong& Li, Yang. 2009. Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese. Journal of Ophthalmology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-477694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Fengju…[et al.]. Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese. Journal of Ophthalmology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-477694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Fengju& Zhu, Tingzhun& Zhou, Zhongjun& Wu, Yudong& Li, Yang. Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese. Journal of Ophthalmology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-477694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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