Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese
Joint Authors
Zhou, Zhongjun
Zhu, Tingzhun
Zhang, Fengju
Wu, Yudong
Li, Yang
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pathological myopia is a severe hereditary ocular disease leading to blindness.
It is urgent and very important to find the pathogenesis and therapy for this disease.
The purpose of the study is to analyze sequences of lumican and decorin genes with pathological myopia(PM) and control subjects to verify the relationship between lumican, decorin genes and PM in Northern Han Chinese.
We collected and analyzed the blood samples of 94 adults (including 12 pedigree cases and 82 sporadic cases) with PM and 90 controls in the northern Han ethnic Chinese.
Genotyping was performed by direct sequencing after polymerase chain reaction(PCR) amplification and allele frequencies were tested for Hardy-Weinberg equilibrium.
Univariate analysis revealed significant differences between two groups for three SNPs: rs3759223 (C→T) and rs17853500 (T→C) of the lumican gene and rs74419 (T→C) of decorin gene with (P<.05) for all their genotype distribution and allele frequency.
There is no significant difference for incidence of these mutations between pedigree and sporadic group (P>.05).
The results suggested that the sequence variants in 5′-regulatory region of lumican gene and 3'UTR of decorin gene were associated significantly with PM in Northern Han Chinese.
Further studies are needed to confirm finally whether the two genes are the virulence genes of PM.
American Psychological Association (APA)
Zhang, Fengju& Zhu, Tingzhun& Zhou, Zhongjun& Wu, Yudong& Li, Yang. 2009. Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese. Journal of Ophthalmology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-477694
Modern Language Association (MLA)
Zhang, Fengju…[et al.]. Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese. Journal of Ophthalmology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-477694
American Medical Association (AMA)
Zhang, Fengju& Zhu, Tingzhun& Zhou, Zhongjun& Wu, Yudong& Li, Yang. Association of Lumican Gene with Susceptibility to Pathological Myopia in the Northern Han Ethnic Chinese. Journal of Ophthalmology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-477694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477694