Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis
المؤلفون المشاركون
Delladetsima, I.
Ladas, Spiros D.
Karamanolis, George
Kelekis, Nikolaos
Chaldeopoulos, Demetrios
Panayiotides, Ioannis
Kouloulias, Vassilis
Papaxoinis, K.
Triantafyllou, K.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role.
Objectives.
To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue.
Methods.
Rectal mucosa biopsies from 11 patients who underwent irradiation for prostate cancer were examined immunohistochemically for the expression of VEGF and CD31 at three time settings—before, at the completion of, and 6 months after radiotherapy.
VEGF expressing vascular endothelial cells and CD31 expressing microvessels were counted separately in 10 high-power fields (HPFs).
VEGF vascular index (VEGF-VI) and microvascular density (MVD) were calculated as the mean number of VEGF positive cells per vessel or the mean number of vessels per HPF, respectively.
Histological features were also evaluated.
Results.
VEGF-VI was significantly higher at the completion of radiotherapy (0.17±0.15 versus 0.41±0.24, P=0.001) declining 6 months after.
MVD increased significantly only 6 months after radiotherapy (7.3±3.2 versus 10.5±3.1, P<0.005).
The histopathological examination revealed inflammatory changes at the completion of radiotherapy regressing in the majority of cases 6 months after.
Conclusions.
Our results showed that in postradiation rectal biopsy specimens neoangiogenesis seems to be inflammation-related and constitutes a significant postradiation component of the tissue injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karamanolis, George& Delladetsima, I.& Kouloulias, Vassilis& Papaxoinis, K.& Panayiotides, Ioannis& Chaldeopoulos, Demetrios…[et al.]. 2013. Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karamanolis, George…[et al.]. Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-477765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karamanolis, George& Delladetsima, I.& Kouloulias, Vassilis& Papaxoinis, K.& Panayiotides, Ioannis& Chaldeopoulos, Demetrios…[et al.]. Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر