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Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis
Joint Authors
Delladetsima, I.
Ladas, Spiros D.
Karamanolis, George
Kelekis, Nikolaos
Chaldeopoulos, Demetrios
Panayiotides, Ioannis
Kouloulias, Vassilis
Papaxoinis, K.
Triantafyllou, K.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role.
Objectives.
To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue.
Methods.
Rectal mucosa biopsies from 11 patients who underwent irradiation for prostate cancer were examined immunohistochemically for the expression of VEGF and CD31 at three time settings—before, at the completion of, and 6 months after radiotherapy.
VEGF expressing vascular endothelial cells and CD31 expressing microvessels were counted separately in 10 high-power fields (HPFs).
VEGF vascular index (VEGF-VI) and microvascular density (MVD) were calculated as the mean number of VEGF positive cells per vessel or the mean number of vessels per HPF, respectively.
Histological features were also evaluated.
Results.
VEGF-VI was significantly higher at the completion of radiotherapy (0.17±0.15 versus 0.41±0.24, P=0.001) declining 6 months after.
MVD increased significantly only 6 months after radiotherapy (7.3±3.2 versus 10.5±3.1, P<0.005).
The histopathological examination revealed inflammatory changes at the completion of radiotherapy regressing in the majority of cases 6 months after.
Conclusions.
Our results showed that in postradiation rectal biopsy specimens neoangiogenesis seems to be inflammation-related and constitutes a significant postradiation component of the tissue injury.
American Psychological Association (APA)
Karamanolis, George& Delladetsima, I.& Kouloulias, Vassilis& Papaxoinis, K.& Panayiotides, Ioannis& Chaldeopoulos, Demetrios…[et al.]. 2013. Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477765
Modern Language Association (MLA)
Karamanolis, George…[et al.]. Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-477765
American Medical Association (AMA)
Karamanolis, George& Delladetsima, I.& Kouloulias, Vassilis& Papaxoinis, K.& Panayiotides, Ioannis& Chaldeopoulos, Demetrios…[et al.]. Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue : Implications for Radiation Proctitis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477765