Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications

المؤلفون المشاركون

Kanninen, Katja
Malm, Tarja
Koistinaho, Jari

المصدر

International Journal of Alzheimer's Disease

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-10-30

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

One of the most extensively used transgenic mouse model of Alzheimer’s disease (AD) is APPswe/PS1dE9 mice, which over express the Swedish mutation of APP together with PS1 deleted in exon 9.

These mice show increase in parenchymal Aβ load with Aβ plaques starting from the age of four months, glial activation, and deficits in cognitive functions at the age of 6 months demonstrated by radial arm water maze and 12-13 months seen with Morris Water Maze test.

As gene transfer technology allows the delivery of DNA into target cells to achieve the expression of a protective or therapeutic protein, and stem cell transplantation may create an environment supporting neuronal functions and clearing Aβ plaques, these therapeutic approaches alone or in combination represent potential therapeutic strategies that need to be tested in relevant animal models before testing in clinics.

Here we review the current utilization of APPswe/PS1dE9 mice in testing gene transfer and cell transplantation aimed at improving the protection of the neurons against Aβ toxicity and also reducing the brain levels of Aβ.

Both gene therapy and cell based therapy may be feasible therapeutic approaches for human AD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Malm, Tarja& Koistinaho, Jari& Kanninen, Katja. 2011. Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477952

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Malm, Tarja…[et al.]. Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-477952

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Malm, Tarja& Koistinaho, Jari& Kanninen, Katja. Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477952

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-477952