Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications
Joint Authors
Kanninen, Katja
Malm, Tarja
Koistinaho, Jari
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
One of the most extensively used transgenic mouse model of Alzheimer’s disease (AD) is APPswe/PS1dE9 mice, which over express the Swedish mutation of APP together with PS1 deleted in exon 9.
These mice show increase in parenchymal Aβ load with Aβ plaques starting from the age of four months, glial activation, and deficits in cognitive functions at the age of 6 months demonstrated by radial arm water maze and 12-13 months seen with Morris Water Maze test.
As gene transfer technology allows the delivery of DNA into target cells to achieve the expression of a protective or therapeutic protein, and stem cell transplantation may create an environment supporting neuronal functions and clearing Aβ plaques, these therapeutic approaches alone or in combination represent potential therapeutic strategies that need to be tested in relevant animal models before testing in clinics.
Here we review the current utilization of APPswe/PS1dE9 mice in testing gene transfer and cell transplantation aimed at improving the protection of the neurons against Aβ toxicity and also reducing the brain levels of Aβ.
Both gene therapy and cell based therapy may be feasible therapeutic approaches for human AD.
American Psychological Association (APA)
Malm, Tarja& Koistinaho, Jari& Kanninen, Katja. 2011. Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477952
Modern Language Association (MLA)
Malm, Tarja…[et al.]. Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-477952
American Medical Association (AMA)
Malm, Tarja& Koistinaho, Jari& Kanninen, Katja. Utilization of APPswePS1dE9 Transgenic Mice in Research of Alzheimer's Disease : Focus on Gene Therapy and Cell-Based Therapy Applications. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477952