Timing of Maternal Exposure to a High Fat Diet and Development of Obesity and Hyperinsulinemia in Male Rat Offspring : Same Metabolic Phenotype, Different Developmental Pathways?
المؤلفون المشاركون
Howie, Graham J.
Vickers, Mark H.
Sloboda, Deborah M.
Reynolds, Clare M.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Offspring born to mothers either fed an obesogenic diet throughout their life or restricted to pregnancy and lactation demonstrate obesity, hyperinsulinemia, and hyperleptinemia, irrespective of their postweaning diet.
We examined whether timing of a maternal obesogenic diet results in differential regulation of pancreatic adipoinsular and inflammatory signaling pathways in offspring.
Methods.
Female Wistar rats were randomized into 3 groups: (1) control (CONT): fed a control diet preconceptionally and during pregnancy and lactation; (2) maternal high fat (MHF): fed an HF diet throughout their life and during pregnancy and lactation; (3) pregnancy and lactation HF (PLHF): fed a control diet throughout life until mating, then HF diet during pregnancy and lactation.
Male offspring were fed the control diet postweaning.
Plasma and pancreatic tissue were collected, and mRNA concentrations of key factors regulating adipoinsular axis signaling were determined.
Results.
MHF and PLHF offspring exhibited increased adiposity and were hyperinsulinemic and hyperleptinemic compared to CONT.
Despite a similar anthropometric phenotype, MHF and PLHF offspring exhibited distinctly different expression for key pancreatic genes, dependent upon maternal preconceptional nutritional background.
Conclusions.
These data suggest that despite using differential signaling pathways, obesity in offspring may be an adaptive outcome of early life exposure to HF during critical developmental windows.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Howie, Graham J.& Sloboda, Deborah M.& Reynolds, Clare M.& Vickers, Mark H.. 2013. Timing of Maternal Exposure to a High Fat Diet and Development of Obesity and Hyperinsulinemia in Male Rat Offspring : Same Metabolic Phenotype, Different Developmental Pathways?. Journal of Nutrition and Metabolism،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-477972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Howie, Graham J.…[et al.]. Timing of Maternal Exposure to a High Fat Diet and Development of Obesity and Hyperinsulinemia in Male Rat Offspring : Same Metabolic Phenotype, Different Developmental Pathways?. Journal of Nutrition and Metabolism No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-477972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Howie, Graham J.& Sloboda, Deborah M.& Reynolds, Clare M.& Vickers, Mark H.. Timing of Maternal Exposure to a High Fat Diet and Development of Obesity and Hyperinsulinemia in Male Rat Offspring : Same Metabolic Phenotype, Different Developmental Pathways?. Journal of Nutrition and Metabolism. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-477972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر