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The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease
المؤلفون المشاركون
Zhang, Ling
Ma, Chun-Mei
Zhu, Hua
Yang, Ya-Jun
Huang, Lan
Liu, Yu
Yao, Zhi-Gang
Liang, Liang
Qin, Chuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Traditional Chinese Medicine (TCM) is a complete medical system that has been practiced for more than 3000 years.
Prescription number 1 (PN-1) consists of several Chinese medicines and is designed according to TCM theories to treat patients with neuropsychiatric disorders.
The evidence of clinical practice suggests the benefit effects of PN-1 on cognitive deficits of dementia patients.
We try to prove and explain this by using contemporary methodology and transgenic animal models of Alzheimer’s disease (AD).
The behavioral studies were developed to evaluate the memory of transgenic animals after intragastric administration of PN-1 for 3 months.
Amyloid beta-protein (Aβ) neuropathology was quantified using immunohistochemistry and ELISA.
The western blotting was used to detect the levels of plasticity associated proteins.
The safety of PN-1 on mice was also assessed through multiple parameters.
Results showed that PN-1 could effectively relieve learning and memory impairment of transgenic animals.
Possible mechanisms showed that PN-1 could significantly reduce plaque burden and Aβ levels and boost synaptic plasticity.
Our observations showed that PN-1 could improve learning and memory ability through multiple mechanisms without detectable side effects on mice.
We propose that PN-1 is a promising alternative treatment for AD in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Zhi-Gang& Zhang, Ling& Liang, Liang& Liu, Yu& Yang, Ya-Jun& Huang, Lan…[et al.]. 2013. The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Zhi-Gang…[et al.]. The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-478081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Zhi-Gang& Zhang, Ling& Liang, Liang& Liu, Yu& Yang, Ya-Jun& Huang, Lan…[et al.]. The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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