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The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease
Joint Authors
Zhang, Ling
Ma, Chun-Mei
Zhu, Hua
Yang, Ya-Jun
Huang, Lan
Liu, Yu
Yao, Zhi-Gang
Liang, Liang
Qin, Chuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Traditional Chinese Medicine (TCM) is a complete medical system that has been practiced for more than 3000 years.
Prescription number 1 (PN-1) consists of several Chinese medicines and is designed according to TCM theories to treat patients with neuropsychiatric disorders.
The evidence of clinical practice suggests the benefit effects of PN-1 on cognitive deficits of dementia patients.
We try to prove and explain this by using contemporary methodology and transgenic animal models of Alzheimer’s disease (AD).
The behavioral studies were developed to evaluate the memory of transgenic animals after intragastric administration of PN-1 for 3 months.
Amyloid beta-protein (Aβ) neuropathology was quantified using immunohistochemistry and ELISA.
The western blotting was used to detect the levels of plasticity associated proteins.
The safety of PN-1 on mice was also assessed through multiple parameters.
Results showed that PN-1 could effectively relieve learning and memory impairment of transgenic animals.
Possible mechanisms showed that PN-1 could significantly reduce plaque burden and Aβ levels and boost synaptic plasticity.
Our observations showed that PN-1 could improve learning and memory ability through multiple mechanisms without detectable side effects on mice.
We propose that PN-1 is a promising alternative treatment for AD in the future.
American Psychological Association (APA)
Yao, Zhi-Gang& Zhang, Ling& Liang, Liang& Liu, Yu& Yang, Ya-Jun& Huang, Lan…[et al.]. 2013. The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478081
Modern Language Association (MLA)
Yao, Zhi-Gang…[et al.]. The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-478081
American Medical Association (AMA)
Yao, Zhi-Gang& Zhang, Ling& Liang, Liang& Liu, Yu& Yang, Ya-Jun& Huang, Lan…[et al.]. The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478081