Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse
المؤلفون المشاركون
Funabiki, Kazuhiko
Tanimoto, Mitsuo
Tomino, Yasuhiko
Gohda, Tomohito
Furukawa, Masako
Horikoshi, Satoshi
Hagiwara, Shinji
المصدر
International Journal of Nephrology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Although angiotensin II-mediated inflammation and extracellular matrix accumulation are considered to be associated with the progression of diabetic nephropathy, these processes have not yet been sufficiently clarified.
The objective of this study was to determine whether the correction of the abnormal renal expression of MMPs and its inhibitors (MMPs/TIMPs) and cytokines following the administration of aliskiren to KK-Ay mice results in a renoprotective effect.
Methods.
KK-Ay mice were divided into two groups, that is, untreated (saline) and treated (aliskiren) groups.
Systolic BP, HbA1c levels, and the albumin-creatinine ratio (ACR) were measured.
The renal expression of MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (pro)renin receptor ((P)RR) was examined using real-time PCR and/or immunohistochemical staining.
Renal MAPK and NF-κB activity were also examined by Western blot analyses and ELISA, respectively.
Results.
Significant decreases in systolic BP and ACR levels were observed in treated KK-Ay mice compared with the findings in untreated KK-Ay mice.
Furthermore, increases in MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (P)RR expression, in addition to MAPK and NF-κB activity, were significantly attenuated by aliskiren administration.
Conclusions.
It appears that aliskiren improves albuminuria and renal fibrosis by regulating inflammation and the alteration of collagen synthesis and degradation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Furukawa, Masako& Gohda, Tomohito& Hagiwara, Shinji& Tanimoto, Mitsuo& Horikoshi, Satoshi& Funabiki, Kazuhiko…[et al.]. 2013. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478131
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Furukawa, Masako…[et al.]. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse. International Journal of Nephrology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-478131
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Furukawa, Masako& Gohda, Tomohito& Hagiwara, Shinji& Tanimoto, Mitsuo& Horikoshi, Satoshi& Funabiki, Kazuhiko…[et al.]. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478131
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478131
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر