Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse
Joint Authors
Funabiki, Kazuhiko
Tanimoto, Mitsuo
Tomino, Yasuhiko
Gohda, Tomohito
Furukawa, Masako
Horikoshi, Satoshi
Hagiwara, Shinji
Source
International Journal of Nephrology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Although angiotensin II-mediated inflammation and extracellular matrix accumulation are considered to be associated with the progression of diabetic nephropathy, these processes have not yet been sufficiently clarified.
The objective of this study was to determine whether the correction of the abnormal renal expression of MMPs and its inhibitors (MMPs/TIMPs) and cytokines following the administration of aliskiren to KK-Ay mice results in a renoprotective effect.
Methods.
KK-Ay mice were divided into two groups, that is, untreated (saline) and treated (aliskiren) groups.
Systolic BP, HbA1c levels, and the albumin-creatinine ratio (ACR) were measured.
The renal expression of MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (pro)renin receptor ((P)RR) was examined using real-time PCR and/or immunohistochemical staining.
Renal MAPK and NF-κB activity were also examined by Western blot analyses and ELISA, respectively.
Results.
Significant decreases in systolic BP and ACR levels were observed in treated KK-Ay mice compared with the findings in untreated KK-Ay mice.
Furthermore, increases in MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (P)RR expression, in addition to MAPK and NF-κB activity, were significantly attenuated by aliskiren administration.
Conclusions.
It appears that aliskiren improves albuminuria and renal fibrosis by regulating inflammation and the alteration of collagen synthesis and degradation.
American Psychological Association (APA)
Furukawa, Masako& Gohda, Tomohito& Hagiwara, Shinji& Tanimoto, Mitsuo& Horikoshi, Satoshi& Funabiki, Kazuhiko…[et al.]. 2013. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478131
Modern Language Association (MLA)
Furukawa, Masako…[et al.]. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse. International Journal of Nephrology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-478131
American Medical Association (AMA)
Furukawa, Masako& Gohda, Tomohito& Hagiwara, Shinji& Tanimoto, Mitsuo& Horikoshi, Satoshi& Funabiki, Kazuhiko…[et al.]. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-Ay Mouse. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478131