Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance
المؤلفون المشاركون
Lopez, Alfonso
Wang, Yanwen
Chen, Yanfeng
Zhang, Junzeng
Sun, Changhao
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The present study was carried out to determine the effect of berberine on glucose homeostasis and several biomarkers associated with insulin sensitivity in male Wistar rats with intraperitoneal injection of streptozotocin (STZ)-induced diabetes.
Rats with fasting blood glucose 16.7 mmol/L after 2 weeks of STZ injection were divided into two groups.
One group was used as the diabetic control and another treated by gavage feeding with 100 mg/kg/d of berberine in water containing 0.5% carboxymethyl cellulose.
A group of rats without receiving STZ was used as the normal control.
After 7 weeks, berberine supplementation moderately but significantly lowered fasting blood glucose levels and improved oral glucose tolerance.
Berberine lowered plasma free fatty acids and C-reactive protein levels without affecting plasma insulin levels.
Diabetic rats treated with berberine showed significantly lower plasma triacylglycerol and cholesterol levels.
Furthermore, berberine inhibited dipeptidyl peptidase-4 and protein tyrosine phosphatase-1B activities.
In conclusion, berberine showed a dramatic effect of lowering blood cholesterol and triacylglycerols and improved moderately glucose homeostasis in STZ-induced diabetic rats in association with multiple factors related to insulin resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yanfeng& Wang, Yanwen& Zhang, Junzeng& Sun, Changhao& Lopez, Alfonso. 2011. Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yanfeng…[et al.]. Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance. ISRN Endocrinology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-478159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yanfeng& Wang, Yanwen& Zhang, Junzeng& Sun, Changhao& Lopez, Alfonso. Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر