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Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance
Joint Authors
Lopez, Alfonso
Wang, Yanwen
Chen, Yanfeng
Zhang, Junzeng
Sun, Changhao
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was carried out to determine the effect of berberine on glucose homeostasis and several biomarkers associated with insulin sensitivity in male Wistar rats with intraperitoneal injection of streptozotocin (STZ)-induced diabetes.
Rats with fasting blood glucose 16.7 mmol/L after 2 weeks of STZ injection were divided into two groups.
One group was used as the diabetic control and another treated by gavage feeding with 100 mg/kg/d of berberine in water containing 0.5% carboxymethyl cellulose.
A group of rats without receiving STZ was used as the normal control.
After 7 weeks, berberine supplementation moderately but significantly lowered fasting blood glucose levels and improved oral glucose tolerance.
Berberine lowered plasma free fatty acids and C-reactive protein levels without affecting plasma insulin levels.
Diabetic rats treated with berberine showed significantly lower plasma triacylglycerol and cholesterol levels.
Furthermore, berberine inhibited dipeptidyl peptidase-4 and protein tyrosine phosphatase-1B activities.
In conclusion, berberine showed a dramatic effect of lowering blood cholesterol and triacylglycerols and improved moderately glucose homeostasis in STZ-induced diabetic rats in association with multiple factors related to insulin resistance.
American Psychological Association (APA)
Chen, Yanfeng& Wang, Yanwen& Zhang, Junzeng& Sun, Changhao& Lopez, Alfonso. 2011. Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478159
Modern Language Association (MLA)
Chen, Yanfeng…[et al.]. Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance. ISRN Endocrinology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-478159
American Medical Association (AMA)
Chen, Yanfeng& Wang, Yanwen& Zhang, Junzeng& Sun, Changhao& Lopez, Alfonso. Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478159