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Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production
المؤلفون المشاركون
Chiuso-Minicucci, Fernanda
Ishikawa, Larissa Lumi Watanabe
Zorzella-Pezavento, Sofia Fernanda Gonçalves
Marques, Camila
França, Thais Graziela Donegá
Sartori, Alexandrina
Ikoma, Maura Rosane Valerio
da Rosa, Larissa Camargo
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Experimental autoimmune encephalomyelitis (EAE) is an artificially induced demyelination of the central nervous system (CNS) that resembles multiple sclerosis in its clinical, histopathological, and immunological features.
Activated Th1 and Th17 cells are thought to be the main immunological players during EAE development.
This study was designed to evaluate peripheral and local contribution of IL-17 to acute and chronic EAE stages.
C57BL/6 mice were immunized with MOG plus complete Freund’s adjuvant followed by pertussis toxin.
Mice presented an initial acute phase characterized by accentuated weight loss and high clinical score, followed by a partial recovery when the animals reached normal body weight and smaller clinical scores.
Spleen cells stimulated with MOG produced significantly higher levels of IFN-γ during the acute period whereas similar IL-17 levels were produced during both disease stages.
CNS-infiltrating cells stimulated with MOG produced similar amounts of IFN-γ but, IL-17 was produced only at the acute phase of EAE.
The percentage of Foxp3+ Treg cells, at the spleen and CNS, was elevated during both phases.
The degree of inflammation was similar at both disease stages.
Partial clinical recovery observed during chronic EAE was associated with no IL-17 production and presence of Foxp3+ Treg cells in the CNS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& da Rosa, Larissa Camargo& Marques, Camila…[et al.]. 2013. Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-478187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zorzella-Pezavento, Sofia Fernanda Gonçalves& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& da Rosa, Larissa Camargo& Marques, Camila…[et al.]. Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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