PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?
المؤلفون المشاركون
Pitta, Ivan da Rocha
de Melo Rego, Moacyr Jesus Barreto
da Rocha Junior, Laurindo Ferreira
Pitta, Maira Galdino da Rocha
Dantas, Andréa Tavares
Duarte, Ângela Luzia Branco Pinto
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Adaptive immunity has evolved as a very powerful and highly specialized tool of host defense.
Its classical protagonists are lymphocytes of the T- and B-cell lineage.
Cytokines and chemokines play a key role as effector mechanisms of the adaptive immunity.
Some autoimmune and inflammatory diseases are caused by disturbance of the adaptive immune system.
Recent advances in understanding the pathogenesis of autoimmune diseases have led to research on new molecular and therapeutic targets.
PPARγ are members of the nuclear receptor superfamily and are transcription factors involved in lipid metabolism as well as innate and adaptive immunity.
PPARγ is activated by synthetic and endogenous ligands.
Previous studies have shown that PPAR agonists regulate T-cell survival, activation and T helper cell differentiation into effector subsets: Th1, Th2, Th17, and Tregs.
PPARγ has also been associated with B cells.
The present review addresses these issues by placing PPARγ agonists in the context of adaptive immune responses and the relation of the activation of these receptors with the expression of cytokines involved in adaptive immunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
da Rocha Junior, Laurindo Ferreira& Dantas, Andréa Tavares& Duarte, Ângela Luzia Branco Pinto& de Melo Rego, Moacyr Jesus Barreto& Pitta, Ivan da Rocha& Pitta, Maira Galdino da Rocha. 2013. PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?. PPAR Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478201
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
da Rocha Junior, Laurindo Ferreira…[et al.]. PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?. PPAR Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-478201
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
da Rocha Junior, Laurindo Ferreira& Dantas, Andréa Tavares& Duarte, Ângela Luzia Branco Pinto& de Melo Rego, Moacyr Jesus Barreto& Pitta, Ivan da Rocha& Pitta, Maira Galdino da Rocha. PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478201
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478201
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر