PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?
Joint Authors
Pitta, Ivan da Rocha
de Melo Rego, Moacyr Jesus Barreto
da Rocha Junior, Laurindo Ferreira
Pitta, Maira Galdino da Rocha
Dantas, Andréa Tavares
Duarte, Ângela Luzia Branco Pinto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Adaptive immunity has evolved as a very powerful and highly specialized tool of host defense.
Its classical protagonists are lymphocytes of the T- and B-cell lineage.
Cytokines and chemokines play a key role as effector mechanisms of the adaptive immunity.
Some autoimmune and inflammatory diseases are caused by disturbance of the adaptive immune system.
Recent advances in understanding the pathogenesis of autoimmune diseases have led to research on new molecular and therapeutic targets.
PPARγ are members of the nuclear receptor superfamily and are transcription factors involved in lipid metabolism as well as innate and adaptive immunity.
PPARγ is activated by synthetic and endogenous ligands.
Previous studies have shown that PPAR agonists regulate T-cell survival, activation and T helper cell differentiation into effector subsets: Th1, Th2, Th17, and Tregs.
PPARγ has also been associated with B cells.
The present review addresses these issues by placing PPARγ agonists in the context of adaptive immune responses and the relation of the activation of these receptors with the expression of cytokines involved in adaptive immunity.
American Psychological Association (APA)
da Rocha Junior, Laurindo Ferreira& Dantas, Andréa Tavares& Duarte, Ângela Luzia Branco Pinto& de Melo Rego, Moacyr Jesus Barreto& Pitta, Ivan da Rocha& Pitta, Maira Galdino da Rocha. 2013. PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?. PPAR Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478201
Modern Language Association (MLA)
da Rocha Junior, Laurindo Ferreira…[et al.]. PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?. PPAR Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-478201
American Medical Association (AMA)
da Rocha Junior, Laurindo Ferreira& Dantas, Andréa Tavares& Duarte, Ângela Luzia Branco Pinto& de Melo Rego, Moacyr Jesus Barreto& Pitta, Ivan da Rocha& Pitta, Maira Galdino da Rocha. PPARγ Agonists in Adaptive Immunity : What Do Immune Disorders and Their Models Have to Tell Us?. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478201