Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins
المؤلفون المشاركون
Calhelha, Ricardo C.
Oliveira, M. Beatriz P. P.
Soković, Marina
Ferreira, Isabel C. F. R.
Queiroz, Maria-João R. P.
Dias, Maria Inês
Barreira, João C. M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Natural matrices are important sources of new antitumor and antimicrobial compounds.
Species such as Laurus nobilis L.
(laurel) might be used for this purpose, considering its medicinal properties.
Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts.
Specifically, methanol and aqueous extracts of wild and cultivated samples of L.
nobilis were compared considering different phenolic groups.
Principal component analysis (PCA) was applied to understand how each extract acts differentially against specific bacteria, fungi, and selected human tumor cell lines.
In general, the extract type induced the highest differences in bioactivity of laurel samples.
However, from the PCA biplot, it became clear that wild laurel samples were higher inhibitors of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15).
HepG2 had the same response to laurel from wild and cultivated origin.
It was also observed that methanolic extracts tended to have higher antimicrobial activity, except against A.
niger, A.
fumigatus, and P.
verrucosum.
The differences in bioactivity might be related to the higher phenolic contents in methanolic extracts.
These results allow selecting the extract type and/or origin with highest antibacterial, antifungal, and antitumor activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dias, Maria Inês& Barreira, João C. M.& Calhelha, Ricardo C.& Queiroz, Maria-João R. P.& Oliveira, M. Beatriz P. P.& Soković, Marina…[et al.]. 2014. Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478260
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dias, Maria Inês…[et al.]. Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-478260
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dias, Maria Inês& Barreira, João C. M.& Calhelha, Ricardo C.& Queiroz, Maria-João R. P.& Oliveira, M. Beatriz P. P.& Soković, Marina…[et al.]. Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478260
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478260
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر