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Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins
Joint Authors
Calhelha, Ricardo C.
Oliveira, M. Beatriz P. P.
Soković, Marina
Ferreira, Isabel C. F. R.
Queiroz, Maria-João R. P.
Dias, Maria Inês
Barreira, João C. M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Natural matrices are important sources of new antitumor and antimicrobial compounds.
Species such as Laurus nobilis L.
(laurel) might be used for this purpose, considering its medicinal properties.
Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts.
Specifically, methanol and aqueous extracts of wild and cultivated samples of L.
nobilis were compared considering different phenolic groups.
Principal component analysis (PCA) was applied to understand how each extract acts differentially against specific bacteria, fungi, and selected human tumor cell lines.
In general, the extract type induced the highest differences in bioactivity of laurel samples.
However, from the PCA biplot, it became clear that wild laurel samples were higher inhibitors of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15).
HepG2 had the same response to laurel from wild and cultivated origin.
It was also observed that methanolic extracts tended to have higher antimicrobial activity, except against A.
niger, A.
fumigatus, and P.
verrucosum.
The differences in bioactivity might be related to the higher phenolic contents in methanolic extracts.
These results allow selecting the extract type and/or origin with highest antibacterial, antifungal, and antitumor activity.
American Psychological Association (APA)
Dias, Maria Inês& Barreira, João C. M.& Calhelha, Ricardo C.& Queiroz, Maria-João R. P.& Oliveira, M. Beatriz P. P.& Soković, Marina…[et al.]. 2014. Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478260
Modern Language Association (MLA)
Dias, Maria Inês…[et al.]. Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-478260
American Medical Association (AMA)
Dias, Maria Inês& Barreira, João C. M.& Calhelha, Ricardo C.& Queiroz, Maria-João R. P.& Oliveira, M. Beatriz P. P.& Soković, Marina…[et al.]. Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478260