![](/images/graphics-bg.png)
Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert
المؤلفون المشاركون
Nitz, Marcello
Taranto, Osvaldir Pereira
de Souza, Luciane Franquelin Gomes
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The objective of this work was to study the coating process of nifedipine extended release pellets using Opadry and Opadry II, in a fluid bed coater with a Wurster insert.
The coating process was studied using a complete experimental design of two factors at two levels for each polymer.
The variables studied were the inlet air temperature and the coating suspension flow rate.
The agglomerate fraction and coating efficiency were the analyzed response variables.
The air temperature was the variable that most influenced the coating efficiency for both polymers.
In addition, a study of the dissolution profiles of coated and uncoated pellets using 0.5% sodium lauryl sulfate in simulated gastric fluid without enzymes (pH 1.2) was conducted.
The results showed a prolonged release profile for the coated and uncoated pellets that was very similar to the standards established by the U.S.
Pharmacopoeia.
The drug content and the release profiles were not significantly affected by storage at 40°C and 75% relative humidity.
However, when exposed to direct sunlight and fluorescent light (light from fluorescent bulbs), the coated pellets lost only 5% of the drug content, while the uncoated ones lost more than 35%; furthermore, the dissolution profile of the uncoated pellets was faster.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Souza, Luciane Franquelin Gomes& Nitz, Marcello& Taranto, Osvaldir Pereira. 2014. Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478283
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Souza, Luciane Franquelin Gomes…[et al.]. Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-478283
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Souza, Luciane Franquelin Gomes& Nitz, Marcello& Taranto, Osvaldir Pereira. Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478283
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478283
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)