Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert
Joint Authors
Nitz, Marcello
Taranto, Osvaldir Pereira
de Souza, Luciane Franquelin Gomes
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The objective of this work was to study the coating process of nifedipine extended release pellets using Opadry and Opadry II, in a fluid bed coater with a Wurster insert.
The coating process was studied using a complete experimental design of two factors at two levels for each polymer.
The variables studied were the inlet air temperature and the coating suspension flow rate.
The agglomerate fraction and coating efficiency were the analyzed response variables.
The air temperature was the variable that most influenced the coating efficiency for both polymers.
In addition, a study of the dissolution profiles of coated and uncoated pellets using 0.5% sodium lauryl sulfate in simulated gastric fluid without enzymes (pH 1.2) was conducted.
The results showed a prolonged release profile for the coated and uncoated pellets that was very similar to the standards established by the U.S.
Pharmacopoeia.
The drug content and the release profiles were not significantly affected by storage at 40°C and 75% relative humidity.
However, when exposed to direct sunlight and fluorescent light (light from fluorescent bulbs), the coated pellets lost only 5% of the drug content, while the uncoated ones lost more than 35%; furthermore, the dissolution profile of the uncoated pellets was faster.
American Psychological Association (APA)
de Souza, Luciane Franquelin Gomes& Nitz, Marcello& Taranto, Osvaldir Pereira. 2014. Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478283
Modern Language Association (MLA)
de Souza, Luciane Franquelin Gomes…[et al.]. Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-478283
American Medical Association (AMA)
de Souza, Luciane Franquelin Gomes& Nitz, Marcello& Taranto, Osvaldir Pereira. Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-478283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478283