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Stability Indicating Liquid Chromatographic Method for Estimation of Trihexyphenidyl Hydrochloride and Risperidone in Tablet Formulation : Development and Validation Consideration
المؤلفون المشاركون
Patel, Mrunali R.
Kartik, Vikani
Patel, Rashmin B.
Mehul, Gopani
Bhaumik, Patel
المصدر
Chromatography Research International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
This paper describes validated reverse phase high-performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of trihexyphenidyl hydrochloride (THP) and risperidone (RSP) in the pure powder form and in combined tablet dosage form.
The HPLC separation was achieved on a core shell C18 (100 mm length × 4.6 mm, 2.6 μm particle size) using methanol : ammonium acetate buffer 1% (85 : 15 v/v; pH-6.5) as mobile phase and delivered at flow rate of 0.8 mL/min.
The calibration plot showed good linear relationship with r2 = 0.997 ± 0.001 for THP and r2 = 0.998 ± 0.001 for RSP in concentration range of 50–175 μg/mL and 50–175 μg/mL, respectively.
LOD and LOQ were found to be 0.40 and 1.29 μg/mL for THP and 1.24 and 3.92 μg/mL for RSP.
Assay of THP and RSP was found to be 100.16 ± 0.03% and 99.83 ± 0.02%, respectively.
THP and RSP were subjected to different stress conditions (acidic, basic, oxidative, thermal, and photolytic degradation).
The degraded product peaks were well resolved from the pure drug peak.
The method was successfully validated as per the ICH guidelines.
The developed RP-HPLC method was successfully applied for the estimation of THP and RSP in tablet dosage form.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bhaumik, Patel& Mehul, Gopani& Kartik, Vikani& Patel, Rashmin B.& Patel, Mrunali R.. 2014. Stability Indicating Liquid Chromatographic Method for Estimation of Trihexyphenidyl Hydrochloride and Risperidone in Tablet Formulation : Development and Validation Consideration. Chromatography Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-478415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bhaumik, Patel…[et al.]. Stability Indicating Liquid Chromatographic Method for Estimation of Trihexyphenidyl Hydrochloride and Risperidone in Tablet Formulation : Development and Validation Consideration. Chromatography Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-478415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bhaumik, Patel& Mehul, Gopani& Kartik, Vikani& Patel, Rashmin B.& Patel, Mrunali R.. Stability Indicating Liquid Chromatographic Method for Estimation of Trihexyphenidyl Hydrochloride and Risperidone in Tablet Formulation : Development and Validation Consideration. Chromatography Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-478415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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