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Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs : Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels
المؤلفون المشاركون
Ko, Sheung-Fat
Lee, Chia-Chang
Lee, Chen-Chang
Chen, Min-Chi
Huang, Chung-Cheng
Sun, Cheuk-Kwan
Ng, Shu-Hang
Yip, Hon-Kan
Sheu, Jiunn-Jye
Leu, Steve
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-14
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This study investigates the therapeutic potential of intracoronary tacrolimus against acute myocardial infarction (AMI) in minipigs with serial cardiac magnetic resonance (CMR) and changes at histological and protein levels.
Twelve minipigs subjected to permanent left anterior descending artery ligation were randomized as tac-treated group (n=6, with intracoronary tacrolimus treatment) and controls (n=6).
CMR with cine and late gadolinium enhancement (LGE) studies were performed on postoperative days 2, 5, and 21.
There were no significant differences in left ventricular function (LVF), contractility, and LGE between the two groups on day 2.
On day 5, the tac-treated group showed a significantly higher ejection fraction, smaller infarct, and lower day-5/day-2 infarct ratio than controls.
On day 21, the controls demonstrated further deterioration of LVF and infarct.
Contrastingly, the tac-treated animals demonstrated preservation of LVF, contractility, significantly smaller infarct, and lower day-21/day-2 infarct ratios compared with those on day 5 and controls.
The in vivo CMR results were correlated with in vitro findings on histology, immunostaining, and Western blotting which revealed significantly less fibrosis, higher vascularities, less CD68+ and CD40+ inflammatory cells, lower expressions of inflammatory (MMP-9, NF-κB, and TNF-α), and apoptotic (Bax, Caspase-3, c-PARP) biomarkers, respectively, in tac-treated AMI minipigs than controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ko, Sheung-Fat& Yip, Hon-Kan& Leu, Steve& Lee, Chen-Chang& Sheu, Jiunn-Jye& Lee, Chia-Chang…[et al.]. 2014. Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs : Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-478495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ko, Sheung-Fat…[et al.]. Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs : Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-478495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ko, Sheung-Fat& Yip, Hon-Kan& Leu, Steve& Lee, Chen-Chang& Sheu, Jiunn-Jye& Lee, Chia-Chang…[et al.]. Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs : Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-478495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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