Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
المؤلفون المشاركون
Beyer, Lothar
Sieler, Joachim
Manzur, Jorge
Spodine, Evgenia
Carrasco, Fernando
Hernández, Wilfredo
Hennig, Lothar
Vaisberg, Abraham
Blaurock, Steffen
Paz, Juan
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2′-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3′-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2′-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1′-nitro-2′-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR).
The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography.
Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement.
The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (IC50=0.01–9.87 μM) exhibited higher antiproliferative activity than their free ligands (IC50=23.48–70.86 and >250 μM) against different types of human tumor cell lines.
Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 μM, resp.).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hernández, Wilfredo& Paz, Juan& Carrasco, Fernando& Vaisberg, Abraham& Spodine, Evgenia& Manzur, Jorge…[et al.]. 2013. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hernández, Wilfredo…[et al.]. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-478561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hernández, Wilfredo& Paz, Juan& Carrasco, Fernando& Vaisberg, Abraham& Spodine, Evgenia& Manzur, Jorge…[et al.]. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر