Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
Joint Authors
Beyer, Lothar
Sieler, Joachim
Manzur, Jorge
Spodine, Evgenia
Carrasco, Fernando
Hernández, Wilfredo
Hennig, Lothar
Vaisberg, Abraham
Blaurock, Steffen
Paz, Juan
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2′-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3′-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2′-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1′-nitro-2′-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR).
The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography.
Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement.
The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (IC50=0.01–9.87 μM) exhibited higher antiproliferative activity than their free ligands (IC50=23.48–70.86 and >250 μM) against different types of human tumor cell lines.
Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 μM, resp.).
American Psychological Association (APA)
Hernández, Wilfredo& Paz, Juan& Carrasco, Fernando& Vaisberg, Abraham& Spodine, Evgenia& Manzur, Jorge…[et al.]. 2013. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478561
Modern Language Association (MLA)
Hernández, Wilfredo…[et al.]. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-478561
American Medical Association (AMA)
Hernández, Wilfredo& Paz, Juan& Carrasco, Fernando& Vaisberg, Abraham& Spodine, Evgenia& Manzur, Jorge…[et al.]. Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478561