Liver Regeneration and Aging : A Current Perspective
المؤلفون المشاركون
Schmucker, Douglas L.
Sanchez, Henry
المصدر
Current Gerontology and Geriatrics Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Many organ systems exhibit significant age-related deficits, but, based on studies in old rodents and elderly humans, the liver appears to be relatively protected from such changes.
A remarkable feature of the liver is its capacity to regenerate its mass following partial hepatectomy.
Reports suggests that aging compromises the liver's regenerative capacity, both in the rate and to the extent the organ's original volume is restored.
There has been modest definitive information as to which cellular and molecular mechanisms regulating hepatic regeneration are affected by aging.
Changes in hepatic sensitivity to growth factors, for example, epidermal growth factor (EGF), appear to influence regeneration in old animals.
Studies have demonstrated (a) a 60% decline in EGF binding to hepatocyte plasma membranes, (b) reduced expression of the hepatic high affinity EGF receptor and (c) a block between G1 and S-phases of the cell cycle in old rats following EGF stimulation.
Recent studies suggest that reduced phosphorylation and dimerization of the EGF receptor, critical steps in the activation of the extracellular signal-regulated kinase pathway and subsequent cell proliferation are responsible.
Other studies have demonstrated that aging affects the upregulation of a Forkhead Box transcription factor, FoxM1B, which is essential for growth hormone-stimulated liver regeneration in hepatectomized mice.
Aging appears to compromise liver regeneration by influencing several pathways, the result of which is a reduction in the rate of regeneration, but not in the capacity to restore the organ to its original volume.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schmucker, Douglas L.& Sanchez, Henry. 2011. Liver Regeneration and Aging : A Current Perspective. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schmucker, Douglas L.& Sanchez, Henry. Liver Regeneration and Aging : A Current Perspective. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-478703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schmucker, Douglas L.& Sanchez, Henry. Liver Regeneration and Aging : A Current Perspective. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر