Liver Regeneration and Aging : A Current Perspective
Joint Authors
Schmucker, Douglas L.
Sanchez, Henry
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Many organ systems exhibit significant age-related deficits, but, based on studies in old rodents and elderly humans, the liver appears to be relatively protected from such changes.
A remarkable feature of the liver is its capacity to regenerate its mass following partial hepatectomy.
Reports suggests that aging compromises the liver's regenerative capacity, both in the rate and to the extent the organ's original volume is restored.
There has been modest definitive information as to which cellular and molecular mechanisms regulating hepatic regeneration are affected by aging.
Changes in hepatic sensitivity to growth factors, for example, epidermal growth factor (EGF), appear to influence regeneration in old animals.
Studies have demonstrated (a) a 60% decline in EGF binding to hepatocyte plasma membranes, (b) reduced expression of the hepatic high affinity EGF receptor and (c) a block between G1 and S-phases of the cell cycle in old rats following EGF stimulation.
Recent studies suggest that reduced phosphorylation and dimerization of the EGF receptor, critical steps in the activation of the extracellular signal-regulated kinase pathway and subsequent cell proliferation are responsible.
Other studies have demonstrated that aging affects the upregulation of a Forkhead Box transcription factor, FoxM1B, which is essential for growth hormone-stimulated liver regeneration in hepatectomized mice.
Aging appears to compromise liver regeneration by influencing several pathways, the result of which is a reduction in the rate of regeneration, but not in the capacity to restore the organ to its original volume.
American Psychological Association (APA)
Schmucker, Douglas L.& Sanchez, Henry. 2011. Liver Regeneration and Aging : A Current Perspective. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478703
Modern Language Association (MLA)
Schmucker, Douglas L.& Sanchez, Henry. Liver Regeneration and Aging : A Current Perspective. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-478703
American Medical Association (AMA)
Schmucker, Douglas L.& Sanchez, Henry. Liver Regeneration and Aging : A Current Perspective. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478703